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Animal studies have failed to reveal evidence of teratogenicity or embryofetal toxicity when administered in doses up to 28 to 98 times MHRD (based on AUC comparisons).

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Although no formal restrictions on fluorouracil have been determined based on lesion size or location, it is most commonly used on smaller superficial BCCs on the trunk and extremities.

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Thus our results demonstrating the effects of imiquimod treatment on NFκB activation and secretion of the cytokines IL-6 and CCL20 in primary keratinocytes indicated an activity beyond TLR7 or TLR8.

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Prior presentation: Much of this work was presented as the author's MSc Thesis in Clinical Dermatology; permission for use granted by St.

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The preferred amounts of drug and fatty acid, and the amounts and types of optional elements used in formulations of the invention are discussed below with particular reference to creams, ointments and adhesive compositions.

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The complementary method of claim 60, wherein the lesion-directed cytodestruction therapy is administered no more than about 14 days prior to the commencement of the application of the field-directed immunotherapy.

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