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HIV-infected patients who are coinfected with hepatitis B may experience clinical symptoms or laboratory evidence of hepatitis when a lamivudine-containing medication is discontinued; most cases are self-limited, but fatalities have been reported; monitor patients closely for at least several months after discontinuation of abacavir and lamivudine.

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RESISTENCIA -Cuando la concentración de un producto antibacteriano es demasiado baja, solo se detiene el crecimiento de los microorganismos más susceptibles, mientras que los menos susceptibles siguen aumentando, generando una resistencia parcial.

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Metabolism: At normal therapeutic dosages the parent compound is metabolized in the liver to sulfate and glucuronide metabolites, while a small amount is metabolized by microsomal mixed function oxidases to a highly reactive intermediate (N-acetyl-imidoquinone) which is conjugated with glutathione and inactivated; at toxic doses (as little as 4 g in a single day) glutathione can become depleted, and conjugation becomes insufficient to meet the metabolic demand causing an increase in N-acetyl-imidoquinone concentration, which is thought to cause hepatic cell necrosis.

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In contrast, the longer nine-day protocol may be better for reliable patients in whom the main concern is introducing the medication very gradually, as the success rate of this protocol was high.

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