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I've started 50 mg 50 days ago, increased to 100 mg in 25 days ago, increased to 150 mg 10 days ago. It has had no effect except for side effect (weight increase and constipation). I don't understand because with Effexor I had a response. Thinking to go to Wellbutrin because of the no weight gain.



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I'm a 30 yr old male. I was on Zoloft for 5 years (gained 40lbs, couldn't ejaculate) then Cymbalta (nasty side effects). For a couple months My Psych doctor let me try Pristiq. I loved it. I had/have awful anxiety and panic attacks with depression. (My anxiety is because of my depression). This medicine worked quick and I'm now in my 7th month at 50mg once a day. The last week, it seemed to dwindle down a little (not sure why?), as my depression and anxiety started coming back. My same doctor just upped my dosage to 100mg a day. I'm hoping it wont let me down! I have to say that Pristiq is the best of 3 anti-depressants/anxiety medicines I have tried. Thanks all and good luck.

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