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It may be helpful to hold the capsule over the food to which you will add the sprinkles.
It is used to treat multiple seizure types and can be used alone or with other seizure medications if needed.
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Controlling certain types of seizures in the treatment of epilepsy.
When divalproex sodium capsules (sprinkle) are used in this patient group, they should be used with extreme caution and as a sole agent.
Medication administration was double-blind and counterbalanced.
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Add-on TreatmentNumber of PatientsBaseline IncidenceExperimental IncidenceDivalproex sodium delayed7516.
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One twelve-month study was conducted to evaluate the safety of Divalproex Sodium Sprinkle Capsules in the indication of partial seizures (169 patients aged 3 to 10 years).
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Epilepsy Ontario wants to see a proactive response to anticipated drug shortages to prevent them from happening in order to reduce the impact on people living with epilepsy.
Encephalopathy associated with Concomitant Topiramate UseConcomitant administration of topiramate and valproic acid has been associated with hyperammonemia with or without encephalopathy in patients who have tolerated either drug alone.
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Phenobarbital has fewer toxic effects on other parts of the body than most anti-epileptic drugs, and drug dependence is rare, given the low doses used for treating epilepsy.
THERE ARE MULTIPLE REPORTS IN THE CLINICAL LITERATURE THAT INDICATE THE USE OF ANTIEPILEPTIC DRUGS DURING PREGNANCY RESULTS IN AN INCREASED INCIDENCE OF CONGENITAL MALFORMATIONS IN OFFSPRING.
Problems with blood clotting are more likely in people who take large amounts of Depakote ER.
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Important Limitations: Because of the risk to the fetus of neural tube defects, other major malformations (e.
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The first study enrolled adult patients who met DSM-III-R criteria for Bipolar Disorder and who were hospitalized for acute mania.
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The primary outcome of 8 consecutive weeks of euthymia, however, reflects a considerably longer period than do the cross-sectional outcomes (response or remission) used in typical efficacy studies.
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Participants were required to abstain from vitamins, as well as all prescription and over-the-counter medications over the course of the study.
Younger children, especially those receiving enzyme inducing drugs, will require larger maintenance doses to attain targeted total and unbound valproate concentrations.
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This lecture focuses on the effects of permanent destruction of the temporal lobes.
Patients with Mitochondrial Disease: There is an increased risk of valproate-induced acute liver failure and resultant deaths in patients with hereditary neurometabolic syndromes caused by DNA mutations of the mitochondrial DNA Polymerase γ (POLG) gene (e.
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The BPRS was the primary outcome measure with side effects assessed with the UKU Side Effect Rating Scale.
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See full prescribing information for DIVALPROEX SODIUM DELAYED-RELEASE TABLETS.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
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The adverse effect profile and efficacy of divalproex sodium compared with valproic acid: a pharmacoepidemiology study.
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In the following article, we review the clinical presentation of bipolar disorder, its epidemiology, and the pharmacokinetics and mechanism of action for divalproex.
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Table 5 lists treatment-emergent adverse reactions which were reported by less then 5% of patients in the high dose valproate group, and for which the incidence was greater than in the low dose group, in a controlled trial of divalproex sodium delayed-release tablets monotherapy treatment of complex partial seizures.
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The relatively recent additions of topiramate and botulinum toxin have made treatment easier, but one must be careful not to add to cognitive disturbances of multiple sclerosis patients with topiramate.
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